Before antibody drugs come onto the market, the antibodies must first be tested on mice.
Last have Researchers at the University of Zurich (UZH) developed Flycodes technologywhich allows up to 25 antibodies to be tested simultaneously in a single mouse. This allows the number of laboratory animals required to be significantly reduced while at the same time improving data quality – an important advance for the development of biotherapeutic approaches.
The new method from Prof. Dr. Markus A. Seeger from the Institute for Medical Microbiology and Dr. Johannes vom Berg from the Institute of Laboratory Animal Science corresponds to the “3R principle” (Replace, Reduce, Refine), which is intended to develop methods that do not require animal testing, that reduce the number of laboratory animals, or that improve the testing and husbandry conditions.